CYP4F12-PTGER1 Fusion FISH Probe
The CYP4F12-PTGER1 Fusion FISH Probe is used to confirm a fusion of the CYP4F12 and PTGER1 genes. The fusion of the CYP4F12 and PTGER1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CYP4F12-PTGER1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-RERE | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-REOR | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-REGO | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-REGR | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-REAQ | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-ORRE | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-OROR | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-ORGO | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-GORE | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-GOOR | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-GOGO | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-GOGR | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-GRRE | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-GROR | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-GRGO | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-GRGR | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-AQRE | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-AQOR | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-AQGO | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-AQGR | 20 (40 μL) | 200 μL |
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| CYP4F12-PTGER1-20-AQAQ | 20 (40 μL) | 200 μL |
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PTGER1 Gene Summary
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]
Gene Name: Prostaglandin E Receptor 1
Chromosome: CHR19: 14583277 -14586174
Locus: 19p13.12
CYP4F12 Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Name: Cytochrome P450 Family 4 Subfamily F Member 12
Chromosome: CHR19: 15783827 -15807984
Locus: 19p13.12
Gene Diseases
The CYP4F12 PTGER1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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