CYP2C18-HELLS Fusion FISH Probe
The CYP2C18-HELLS Fusion FISH Probe is used to confirm a fusion of the CYP2C18 and HELLS genes. The fusion of the CYP2C18 and HELLS genes has been associated with Liver Hepatocellular Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CYP2C18-HELLS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-RERE | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-REOR | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-REGO | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-REGR | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-REAQ | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-ORRE | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-OROR | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-ORGO | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-ORAQ | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-GORE | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-GOOR | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-GOGO | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-GOGR | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-GOAQ | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-GRRE | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-GROR | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-GRGO | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-GRGR | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-GRAQ | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-AQRE | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-AQOR | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-AQGO | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-AQGR | 20 (40 μL) | 200 μL |
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| CYP2C18-HELLS-20-AQAQ | 20 (40 μL) | 200 μL |
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CYP2C18 Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Cytochrome P450 Family 2 Subfamily C Member 18
Chromosome: CHR10: 96443250 -96495947
Locus: 10q23.33
HELLS Gene Summary
This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014]
Gene Name: Helicase, Lymphoid Specific
Chromosome: CHR10: 96305573 -96361856
Locus: 10q23.33
Gene Diseases
The CYP2C18 HELLS Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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