CYP27A1-STK36 Fusion FISH Probe
The CYP27A1-STK36 Fusion FISH Probe is used to confirm a fusion of the CYP27A1 and STK36 genes. The fusion of the CYP27A1 and STK36 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CYP27A1-STK36-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-RERE | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-REOR | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-REGO | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-REGR | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-REAQ | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-ORRE | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-OROR | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-ORGO | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-ORAQ | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-GORE | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-GOOR | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-GOGO | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-GOGR | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-GOAQ | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-GRRE | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-GROR | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-GRGO | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-GRGR | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-GRAQ | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-AQRE | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-AQOR | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-AQGO | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-AQGR | 20 (40 μL) | 200 μL |
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| CYP27A1-STK36-20-AQAQ | 20 (40 μL) | 200 μL |
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CYP27A1 Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease. [provided by RefSeq, Jul 2008]
Gene Name: Cytochrome P450 Family 27 Subfamily A Member 1
Chromosome: CHR2: 219646471 -219680016
Locus: 2q35
STK36 Gene Summary
This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Serine/threonine Kinase 36
Chromosome: CHR2: 219536748 -219567440
Locus: 2q35
Gene Diseases
The CYP27A1 STK36 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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