CYFIP1-ACACA Fusion FISH Probe
The CYFIP1-ACACA Fusion FISH Probe is used to confirm a fusion of the CYFIP1 and ACACA genes. The fusion of the CYFIP1 and ACACA genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CYFIP1-ACACA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-RERE | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-REOR | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-REGO | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-REGR | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-REAQ | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-ORRE | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-OROR | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-ORGO | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-ORAQ | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-GORE | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-GOOR | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-GOGO | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-GOGR | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-GOAQ | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-GRRE | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-GROR | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-GRGO | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-GRGR | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-GRAQ | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-AQRE | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-AQOR | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-AQGO | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-AQGR | 20 (40 μL) | 200 μL |
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| CYFIP1-ACACA-20-AQAQ | 20 (40 μL) | 200 μL |
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ACACA Gene Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Acetyl-CoA Carboxylase Alpha
Chromosome: CHR17: 35441926 -35766902
Locus: 17q12
CYFIP1 Gene Summary
This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, May 2017]
Gene Name: Cytoplasmic FMR1 Interacting Protein 1
Chromosome: CHR15: 22892683 -23003603
Locus: 15q11.2
Gene Diseases
The CYFIP1 ACACA Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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