CYB5R4-RIPPLY2 Fusion FISH Probe
The CYB5R4-RIPPLY2 Fusion FISH Probe is used to confirm a fusion of the CYB5R4 and RIPPLY2 genes. The fusion of the CYB5R4 and RIPPLY2 genes has been associated with Thymoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CYB5R4-RIPPLY2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-RERE | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-REOR | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-REGO | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-REGR | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-REAQ | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-ORRE | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-OROR | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-ORGO | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-GORE | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-GOOR | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-GOGO | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-GOGR | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-GRRE | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-GROR | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-GRGO | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-GRGR | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-AQRE | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-AQOR | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-AQGO | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-AQGR | 20 (40 μL) | 200 μL |
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| CYB5R4-RIPPLY2-20-AQAQ | 20 (40 μL) | 200 μL |
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CYB5R4 Gene Summary
NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010]
Gene Name: Cytochrome B5 Reductase 4
Chromosome: CHR6: 84569369 -84670146
Locus: 6q14.2
RIPPLY2 Gene Summary
This gene encodes a nuclear protein that belongs to a novel family of proteins required for vertebrate somitogenesis. Members of this family have a tetrapeptide WRPW motif that is required for interaction with the transcriptional repressor Groucho and a carboxy-terminal Ripply homology domain/Bowline-DSCR-Ledgerline conserved region required for transcriptional repression. Null mutant mice die soon after birth and display defects in axial skeleton segmentation due to defective somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: Ripply Transcriptional Repressor 2
Chromosome: CHR6: 84562984 -84567234
Locus: 6q14.2
Gene Diseases
The CYB5R4 RIPPLY2 Fusion has been associated with the following diseases:
| Disease Name |
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| Thymoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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