CXCR4-CFLAR Fusion FISH Probe
The CXCR4-CFLAR Fusion FISH Probe is used to confirm a fusion of the CXCR4 and CFLAR genes. The fusion of the CXCR4 and CFLAR genes has been associated with Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CXCR4-CFLAR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-RERE | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-REOR | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-REGO | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-REGR | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-REAQ | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-ORRE | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-OROR | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-ORGO | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-ORAQ | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-GORE | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-GOOR | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-GOGO | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-GOGR | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-GOAQ | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-GRRE | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-GROR | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-GRGO | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-GRGR | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-GRAQ | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-AQRE | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-AQOR | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-AQGO | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-AQGR | 20 (40 μL) | 200 μL |
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| CXCR4-CFLAR-20-AQAQ | 20 (40 μL) | 200 μL |
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CXCR4 Gene Summary
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: C-X-C Motif Chemokine Receptor 4
Chromosome: CHR2: 136871918 -136875725
Locus: 2q22.1
CFLAR Gene Summary
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Gene Name: CASP8 And FADD Like Apoptosis Regulator
Chromosome: CHR2: 201980876 -202037411
Locus: 2q33.1
Gene Diseases
The CXCR4 CFLAR Fusion has been associated with the following diseases:
| Disease Name |
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| Lymphoid Neoplasm Diffuse Large B-cell Lymphoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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