CXADR-APP Fusion FISH Probe
The CXADR-APP Fusion FISH Probe is used to confirm a fusion of the CXADR and APP genes. The fusion of the CXADR and APP genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CXADR-APP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-RERE | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-REOR | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-REGO | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-REGR | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-REAQ | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-ORRE | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-OROR | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-ORGO | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-ORAQ | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-GORE | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-GOOR | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-GOGO | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-GOGR | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-GOAQ | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-GRRE | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-GROR | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-GRGO | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-GRGR | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-GRAQ | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-AQRE | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-AQOR | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-AQGO | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-AQGR | 20 (40 μL) | 200 μL |
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| CXADR-APP-20-AQAQ | 20 (40 μL) | 200 μL |
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APP Gene Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Gene Name: Amyloid Beta Precursor Protein
Chromosome: CHR21: 27252860 -27543446
Locus: 21q21.3
CXADR Gene Summary
The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
Gene Name: CXADR, Ig-like Cell Adhesion Molecule
Chromosome: CHR21: 18885223 -18965897
Locus: 21q21.1
Gene Diseases
The CXADR APP Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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