CWC25-PRKAR1A Fusion FISH Probe
The CWC25-PRKAR1A Fusion FISH Probe is used to confirm a fusion of the CWC25 and PRKAR1A genes. The fusion of the CWC25 and PRKAR1A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CWC25-PRKAR1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-RERE | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-REOR | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-REGO | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-REGR | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-REAQ | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-ORRE | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-OROR | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-ORGO | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-GORE | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-GOOR | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-GOGO | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-GOGR | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-GRRE | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-GROR | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-GRGO | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-GRGR | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-AQRE | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-AQOR | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-AQGO | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-AQGR | 20 (40 μL) | 200 μL |
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| CWC25-PRKAR1A-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKAR1A Gene Summary
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]
Gene Name: Protein Kinase CAMP-dependent Type I Regulatory Subunit Alpha
Chromosome: CHR17: 66508109 -66528910
Locus: 17q24.2
CWC25 Gene Summary
This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. [provided by RefSeq, Nov 2012]
Gene Name: CWC25 Spliceosome Associated Protein Homolog
Chromosome: CHR17: 36957445 -36981589
Locus: 17q12
Gene Diseases
The CWC25 PRKAR1A Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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