CUL3-IRS1 Fusion FISH Probe
The CUL3-IRS1 Fusion FISH Probe is used to confirm a fusion of the CUL3 and IRS1 genes. The fusion of the CUL3 and IRS1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CUL3-IRS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-RERE | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-REOR | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-REGO | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-REGR | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-REAQ | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-ORRE | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-OROR | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-ORGO | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-GORE | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-GOOR | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-GOGO | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-GOGR | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-GRRE | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-GROR | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-GRGO | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-GRGR | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-AQRE | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-AQOR | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-AQGO | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-AQGR | 20 (40 μL) | 200 μL |
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| CUL3-IRS1-20-AQAQ | 20 (40 μL) | 200 μL |
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IRS1 Gene Summary
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
Gene Name: Insulin Receptor Substrate 1
Chromosome: CHR2: 227596032 -227663506
Locus: 2q36.3
CUL3 Gene Summary
This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: Cullin 3
Chromosome: CHR2: 225334868 -225450110
Locus: 2q36.2
Gene Diseases
The CUL3 IRS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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