CTTN-PSME2 Fusion FISH Probe
The CTTN-PSME2 Fusion FISH Probe is used to confirm a fusion of the CTTN and PSME2 genes. The fusion of the CTTN and PSME2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTTN-PSME2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-RERE | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-REOR | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-REGO | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-REGR | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-REAQ | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-ORRE | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-OROR | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-ORGO | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-GORE | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-GOOR | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-GOGO | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-GOGR | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-GRRE | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-GROR | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-GRGO | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-GRGR | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-AQRE | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-AQOR | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-AQGO | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-AQGR | 20 (40 μL) | 200 μL |
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| CTTN-PSME2-20-AQAQ | 20 (40 μL) | 200 μL |
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CTTN Gene Summary
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
Gene Name: Cortactin
Chromosome: CHR11: 70244611 -70282690
Locus: 11q13.3
PSME2 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008]
Gene Name: Proteasome Activator Subunit 2
Chromosome: CHR14: 24612573 -24615855
Locus: 14q12
Gene Diseases
The CTTN PSME2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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