CTTN-CBS Fusion FISH Probe
The CTTN-CBS Fusion FISH Probe is used to confirm a fusion of the CTTN and CBS genes. The fusion of the CTTN and CBS genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTTN-CBS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-RERE | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-REOR | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-REGO | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-REGR | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-REAQ | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-ORRE | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-OROR | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-ORGO | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-GORE | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-GOOR | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-GOGO | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-GOGR | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-GRRE | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-GROR | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-GRGO | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-GRGR | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-AQRE | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-AQOR | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-AQGO | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-AQGR | 20 (40 μL) | 200 μL |
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| CTTN-CBS-20-AQAQ | 20 (40 μL) | 200 μL |
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CBS Gene Summary
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
Gene Name: Cystathionine-beta-synthase
Chromosome: CHR21: 44473300 -44496472
Locus: 21q22.3
CTTN Gene Summary
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
Gene Name: Cortactin
Chromosome: CHR11: 70244611 -70282690
Locus: 11q13.3
Gene Diseases
The CTTN CBS Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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