CTSH-RASGRF1 Fusion FISH Probe
The CTSH-RASGRF1 Fusion FISH Probe is used to confirm a fusion of the CTSH and RASGRF1 genes. The fusion of the CTSH and RASGRF1 genes has been associated with Lung Adenocarcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTSH-RASGRF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-RERE | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-REOR | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-REGO | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-REGR | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-REAQ | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-ORRE | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-OROR | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-ORGO | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-GORE | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-GOOR | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-GOGO | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-GOGR | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-GRRE | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-GROR | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-GRGO | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-GRGR | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-AQRE | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-AQOR | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-AQGO | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-AQGR | 20 (40 μL) | 200 μL |
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| CTSH-RASGRF1-20-AQAQ | 20 (40 μL) | 200 μL |
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CTSH Gene Summary
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Gene Name: Cathepsin H
Chromosome: CHR15: 79214091 -79237420
Locus: 15q25.1
RASGRF1 Gene Summary
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]
Gene Name: Ras Protein Specific Guanine Nucleotide Releasing Factor 1
Chromosome: CHR15: 79252288 -79383215
Locus: 15q25.1
Gene Diseases
The CTSH RASGRF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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