CTSD-ARFGEF2 Fusion FISH Probe
The CTSD-ARFGEF2 Fusion FISH Probe is used to confirm a fusion of the CTSD and ARFGEF2 genes. The fusion of the CTSD and ARFGEF2 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTSD-ARFGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| CTSD-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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CTSD Gene Summary
This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]
Gene Name: Cathepsin D
Chromosome: CHR11: 1773981 -1785222
Locus: 11p15.5
ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
Gene Diseases
The CTSD ARFGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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