CTSB-PLAT Fusion FISH Probe
The CTSB-PLAT Fusion FISH Probe is used to confirm a fusion of the CTSB and PLAT genes. The fusion of the CTSB and PLAT genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTSB-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| CTSB-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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CTSB Gene Summary
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]
Gene Name: Cathepsin B
Chromosome: CHR8: 11700033 -11725646
Locus: 8p23.1
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The CTSB PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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