CTSB-FOXP1 Fusion FISH Probe
The CTSB-FOXP1 Fusion FISH Probe is used to confirm a fusion of the CTSB and FOXP1 genes. The fusion of the CTSB and FOXP1 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTSB-FOXP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-RERE | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-REOR | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-REGO | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-REGR | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-REAQ | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-ORRE | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-OROR | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-ORGO | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-GORE | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-GOOR | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-GOGO | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-GOGR | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-GRRE | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-GROR | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-GRGO | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-GRGR | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-AQRE | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-AQOR | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-AQGO | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-AQGR | 20 (40 μL) | 200 μL |
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| CTSB-FOXP1-20-AQAQ | 20 (40 μL) | 200 μL |
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CTSB Gene Summary
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]
Gene Name: Cathepsin B
Chromosome: CHR8: 11700033 -11725646
Locus: 8p23.1
FOXP1 Gene Summary
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Forkhead Box P1
Chromosome: CHR3: 71004735 -71633140
Locus: 3p13
Gene Diseases
The CTSB FOXP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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