CTSB-CBS Fusion FISH Probe
The CTSB-CBS Fusion FISH Probe is used to confirm a fusion of the CTSB and CBS genes. The fusion of the CTSB and CBS genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTSB-CBS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-RERE | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-REOR | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-REGO | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-REGR | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-REAQ | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-ORRE | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-OROR | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-ORGO | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-GORE | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-GOOR | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-GOGO | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-GOGR | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-GRRE | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-GROR | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-GRGO | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-GRGR | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-AQRE | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-AQOR | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-AQGO | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-AQGR | 20 (40 μL) | 200 μL |
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| CTSB-CBS-20-AQAQ | 20 (40 μL) | 200 μL |
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CBS Gene Summary
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
Gene Name: Cystathionine-beta-synthase
Chromosome: CHR21: 44473300 -44496472
Locus: 21q22.3
CTSB Gene Summary
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]
Gene Name: Cathepsin B
Chromosome: CHR8: 11700033 -11725646
Locus: 8p23.1
Gene Diseases
The CTSB CBS Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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