CTNNB1-THRB Fusion FISH Probe
The CTNNB1-THRB Fusion FISH Probe is used to confirm a fusion of the CTNNB1 and THRB genes. The fusion of the CTNNB1 and THRB genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTNNB1-THRB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-RERE | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-REOR | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-REGO | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-REGR | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-REAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-ORRE | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-OROR | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-ORGO | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-GORE | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-GOOR | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-GOGO | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-GOGR | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-GRRE | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-GROR | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-GRGO | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-GRGR | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-AQRE | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-AQOR | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-AQGO | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-AQGR | 20 (40 μL) | 200 μL |
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| CTNNB1-THRB-20-AQAQ | 20 (40 μL) | 200 μL |
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CTNNB1 Gene Summary
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Gene Name: Catenin Beta 1
Chromosome: CHR3: 41240941 -41281939
Locus: 3p22.1
THRB Gene Summary
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Thyroid Hormone Receptor Beta
Chromosome: CHR3: 24158644 -24536313
Locus: 3p24.2
Gene Diseases
The CTNNB1 THRB Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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