CTNNB1-DOCK3 Fusion FISH Probe
The CTNNB1-DOCK3 Fusion FISH Probe is used to confirm a fusion of the CTNNB1 and DOCK3 genes. The fusion of the CTNNB1 and DOCK3 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTNNB1-DOCK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-RERE | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-REOR | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-REGO | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-REGR | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-REAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-ORRE | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-OROR | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-ORGO | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-GORE | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-GOOR | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-GOGO | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-GOGR | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-GRRE | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-GROR | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-GRGO | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-GRGR | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-AQRE | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-AQOR | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-AQGO | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-AQGR | 20 (40 μL) | 200 μL |
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| CTNNB1-DOCK3-20-AQAQ | 20 (40 μL) | 200 μL |
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CTNNB1 Gene Summary
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Gene Name: Catenin Beta 1
Chromosome: CHR3: 41240941 -41281939
Locus: 3p22.1
DOCK3 Gene Summary
This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
Gene Name: Dedicator Of Cytokinesis 3
Chromosome: CHR3: 50712671 -51421629
Locus: 3p21.2
Gene Diseases
The CTNNB1 DOCK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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