CTNNA1-COTL1 Fusion FISH Probe
The CTNNA1-COTL1 Fusion FISH Probe is used to confirm a fusion of the CTNNA1 and COTL1 genes. The fusion of the CTNNA1 and COTL1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTNNA1-COTL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-RERE | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-REOR | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-REGO | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-REGR | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-REAQ | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-ORRE | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-OROR | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-ORGO | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-GORE | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-GOOR | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-GOGO | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-GOGR | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-GRRE | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-GROR | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-GRGO | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-GRGR | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-AQRE | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-AQOR | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-AQGO | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-AQGR | 20 (40 μL) | 200 μL |
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| CTNNA1-COTL1-20-AQAQ | 20 (40 μL) | 200 μL |
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CTNNA1 Gene Summary
This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016]
Gene Name: Catenin Alpha 1
Chromosome: CHR5: 138089106 -138270723
Locus: 5q31.2
COTL1 Gene Summary
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]
Gene Name: Coactosin Like F-actin Binding Protein 1
Chromosome: CHR16: 84599203 -84651669
Locus: 16q24.1
Gene Diseases
The CTNNA1 COTL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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