CTDP1-NFATC1 Fusion FISH Probe
The CTDP1-NFATC1 Fusion FISH Probe is used to confirm a fusion of the CTDP1 and NFATC1 genes. The fusion of the CTDP1 and NFATC1 genes has been associated with Acute Myeloid Leukemia, and Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTDP1-NFATC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-RERE | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-REOR | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-REGO | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-REGR | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-REAQ | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-ORRE | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-OROR | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-ORGO | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-GORE | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-GOOR | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-GOGO | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-GOGR | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-GRRE | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-GROR | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-GRGO | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-GRGR | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-AQRE | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-AQOR | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-AQGO | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-AQGR | 20 (40 μL) | 200 μL |
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| CTDP1-NFATC1-20-AQAQ | 20 (40 μL) | 200 μL |
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NFATC1 Gene Summary
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]
Gene Name: Nuclear Factor Of Activated T-cells 1
Chromosome: CHR18: 77155771 -77289323
Locus: 18q23
CTDP1 Gene Summary
This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Gene Name: CTD Phosphatase Subunit 1
Chromosome: CHR18: 77439800 -77514510
Locus: 18q23
Gene Diseases
The CTDP1 NFATC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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