CTCF-HSD11B2 Fusion FISH Probe
The CTCF-HSD11B2 Fusion FISH Probe is used to confirm a fusion of the CTCF and HSD11B2 genes. The fusion of the CTCF and HSD11B2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTCF-HSD11B2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-RERE | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-REOR | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-REGO | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-REGR | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-REAQ | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-ORRE | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-OROR | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-ORGO | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-GORE | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-GOOR | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-GOGO | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-GOGR | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-GRRE | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-GROR | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-GRGO | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-GRGR | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-AQRE | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-AQOR | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-AQGO | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-AQGR | 20 (40 μL) | 200 μL |
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| CTCF-HSD11B2-20-AQAQ | 20 (40 μL) | 200 μL |
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HSD11B2 Gene Summary
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
Gene Name: Hydroxysteroid 11-beta Dehydrogenase 2
Chromosome: CHR16: 67465035 -67471454
Locus: 16q22.1
CTCF Gene Summary
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Name: CCCTC-binding Factor
Chromosome: CHR16: 67596309 -67673088
Locus: 16q22.1
Gene Diseases
The CTCF HSD11B2 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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