CTBP2-MGMT Fusion FISH Probe
The CTBP2-MGMT Fusion FISH Probe is used to confirm a fusion of the CTBP2 and MGMT genes. The fusion of the CTBP2 and MGMT genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTBP2-MGMT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-RERE | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-REOR | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-REGO | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-REGR | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-REAQ | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-ORRE | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-OROR | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-ORGO | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-GORE | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-GOOR | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-GOGO | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-GOGR | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-GRRE | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-GROR | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-GRGO | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-GRGR | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-AQRE | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-AQOR | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-AQGO | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-AQGR | 20 (40 μL) | 200 μL |
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| CTBP2-MGMT-20-AQAQ | 20 (40 μL) | 200 μL |
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CTBP2 Gene Summary
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Gene Name: C-terminal Binding Protein 2
Chromosome: CHR10: 126676417 -126849624
Locus: 10q26.13
MGMT Gene Summary
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
Gene Name: O-6-methylguanine-DNA Methyltransferase
Chromosome: CHR10: 131265453 -131565783
Locus: 10q26.3
Gene Diseases
The CTBP2 MGMT Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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