CSTA-CASR Fusion FISH Probe
The CSTA-CASR Fusion FISH Probe is used to confirm a fusion of the CSTA and CASR genes. The fusion of the CSTA and CASR genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CSTA-CASR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-RERE | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-REOR | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-REGO | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-REGR | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-REAQ | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-ORRE | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-OROR | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-ORGO | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-ORAQ | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-GORE | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-GOOR | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-GOGO | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-GOGR | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-GOAQ | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-GRRE | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-GROR | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-GRGO | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-GRGR | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-GRAQ | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-AQRE | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-AQOR | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-AQGO | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-AQGR | 20 (40 μL) | 200 μL |
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| CSTA-CASR-20-AQAQ | 20 (40 μL) | 200 μL |
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CASR Gene Summary
The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]
Gene Name: Calcium Sensing Receptor
Chromosome: CHR3: 121902529 -122005344
Locus: 3q13.33-q21.1
CSTA Gene Summary
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]
Gene Name: Cystatin A
Chromosome: CHR3: 122044010 -122060815
Locus: 3q21.1
Gene Diseases
The CSTA CASR Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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