CSE1L-LETM2 Fusion FISH Probe
The CSE1L-LETM2 Fusion FISH Probe is used to confirm a fusion of the CSE1L and LETM2 genes. The fusion of the CSE1L and LETM2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CSE1L-LETM2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-RERE | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-REOR | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-REGO | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-REGR | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-REAQ | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-ORRE | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-OROR | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-ORGO | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-GORE | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-GOOR | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-GOGO | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-GOGR | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-GRRE | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-GROR | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-GRGO | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-GRGR | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-AQRE | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-AQOR | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-AQGO | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-AQGR | 20 (40 μL) | 200 μL |
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| CSE1L-LETM2-20-AQAQ | 20 (40 μL) | 200 μL |
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CSE1L Gene Summary
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Chromosome Segregation 1 Like
Chromosome: CHR20: 47662837 -47713486
Locus: 20q13.13
LETM2 Gene Summary
The Leucine Zipper And EF-hand Containing Transmembrane Protein 2 (LETM2) gene is located on chr8 :38243958-38266062 at 8p11.23.
Gene Name: Leucine Zipper And EF-hand Containing Transmembrane Protein 2
Chromosome: CHR8: 38243958 -38266062
Locus: 8p11.23
Gene Diseases
The CSE1L LETM2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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