CSE1L-ARFGEF2 Fusion FISH Probe
The CSE1L-ARFGEF2 Fusion FISH Probe is used to confirm a fusion of the CSE1L and ARFGEF2 genes. The fusion of the CSE1L and ARFGEF2 genes has been associated with Skin Cutaneous Melanoma, Kidney Renal Clear Cell Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CSE1L-ARFGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| CSE1L-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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CSE1L Gene Summary
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Chromosome Segregation 1 Like
Chromosome: CHR20: 47662837 -47713486
Locus: 20q13.13
ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
Gene Diseases
The CSE1L ARFGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
| Kidney Renal Clear Cell Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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