CRTC3-MESP2 Fusion FISH Probe
The CRTC3-MESP2 Fusion FISH Probe is used to confirm a fusion of the CRTC3 and MESP2 genes. The fusion of the CRTC3 and MESP2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CRTC3-MESP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-RERE | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-REOR | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-REGO | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-REGR | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-REAQ | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-ORRE | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-OROR | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-ORGO | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-GORE | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-GOOR | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-GOGO | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-GOGR | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-GRRE | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-GROR | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-GRGO | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-GRGR | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-AQRE | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-AQOR | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-AQGO | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-AQGR | 20 (40 μL) | 200 μL |
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| CRTC3-MESP2-20-AQAQ | 20 (40 μL) | 200 μL |
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CRTC3 Gene Summary
This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Gene Name: CREB Regulated Transcription Coactivator 3
Chromosome: CHR15: 91073197 -91188577
Locus: 15q26.1
MESP2 Gene Summary
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008]
Gene Name: Mesoderm Posterior BHLH Transcription Factor 2
Chromosome: CHR15: 90319588 -90321982
Locus: 15q26.1
Gene Diseases
The CRTC3 MESP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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