CRTC3-IQGAP1 Fusion FISH Probe
The CRTC3-IQGAP1 Fusion FISH Probe is used to confirm a fusion of the CRTC3 and IQGAP1 genes. The fusion of the CRTC3 and IQGAP1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CRTC3-IQGAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-RERE | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-REOR | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-REGO | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-REGR | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-OROR | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-GORE | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-GROR | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| CRTC3-IQGAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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IQGAP1 Gene Summary
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
Gene Name: IQ Motif Containing GTPase Activating Protein 1
Chromosome: CHR15: 90931472 -91045475
Locus: 15q26.1
CRTC3 Gene Summary
This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Gene Name: CREB Regulated Transcription Coactivator 3
Chromosome: CHR15: 91073197 -91188577
Locus: 15q26.1
Gene Diseases
The CRTC3 IQGAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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