CRLS1-CDS2 Fusion FISH Probe
The CRLS1-CDS2 Fusion FISH Probe is used to confirm a fusion of the CRLS1 and CDS2 genes. The fusion of the CRLS1 and CDS2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CRLS1-CDS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-RERE | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-REOR | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-REGO | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-REGR | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-REAQ | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-ORRE | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-OROR | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-ORGO | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-GORE | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-GOOR | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-GOGO | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-GOGR | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-GRRE | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-GROR | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-GRGO | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-GRGR | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-AQRE | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-AQOR | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-AQGO | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-AQGR | 20 (40 μL) | 200 μL |
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| CRLS1-CDS2-20-AQAQ | 20 (40 μL) | 200 μL |
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CDS2 Gene Summary
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]
Gene Name: CDP-diacylglycerol Synthase 2
Chromosome: CHR20: 5107406 -5178533
Locus: 20p12.3
CRLS1 Gene Summary
This gene encodes a member of the CDP-alcohol phosphatidyltransferase class-I family of proteins. The encoded enzyme catalyzes the synthesis of cardiolipin, a phospholipid component of mitochondrial membranes that is critical for mitochondrial function. [provided by RefSeq, Apr 2016]
Gene Name: Cardiolipin Synthase 1
Chromosome: CHR20: 5986738 -6020697
Locus: 20p12.3
Gene Diseases
The CRLS1 CDS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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