CRLF3-CRHR1 Fusion FISH Probe
The CRLF3-CRHR1 Fusion FISH Probe is used to confirm a fusion of the CRLF3 and CRHR1 genes. The fusion of the CRLF3 and CRHR1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CRLF3-CRHR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-RERE | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-REOR | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-REGO | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-REGR | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-REAQ | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-ORRE | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-OROR | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-ORGO | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-GORE | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-GOOR | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-GOGO | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-GOGR | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-GRRE | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-GROR | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-GRGO | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-GRGR | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-AQRE | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-AQOR | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-AQGO | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-AQGR | 20 (40 μL) | 200 μL |
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| CRLF3-CRHR1-20-AQAQ | 20 (40 μL) | 200 μL |
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CRHR1 Gene Summary
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016]
Gene Name: Corticotropin Releasing Hormone Receptor 1
Chromosome: CHR17_ctg5_hap1: 954314 -1170453
Locus: 17q21.31
CRLF3 Gene Summary
This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]
Gene Name: Cytokine Receptor Like Factor 3
Chromosome: CHR17: 29109701 -29151778
Locus: 17q11.2
Gene Diseases
The CRLF3 CRHR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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