CRKL-GRAMD4 Fusion FISH Probe
The CRKL-GRAMD4 Fusion FISH Probe is used to confirm a fusion of the CRKL and GRAMD4 genes. The fusion of the CRKL and GRAMD4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CRKL-GRAMD4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-RERE | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-REOR | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-REGO | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-REGR | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-REAQ | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-ORRE | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-OROR | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-ORGO | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-GORE | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-GOOR | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-GOGO | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-GOGR | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-GRRE | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-GROR | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-GRGO | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-GRGR | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-AQRE | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-AQOR | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-AQGO | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-AQGR | 20 (40 μL) | 200 μL |
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| CRKL-GRAMD4-20-AQAQ | 20 (40 μL) | 200 μL |
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CRKL Gene Summary
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
Gene Name: CRK Like Proto-oncogene, Adaptor Protein
Chromosome: CHR22: 21271713 -21308037
Locus: 22q11.21
GRAMD4 Gene Summary
GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011]
Gene Name: GRAM Domain Containing 4
Chromosome: CHR22: 47022657 -47075688
Locus: 22q13.31
Gene Diseases
The CRKL GRAMD4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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