CRK-GTF2I Fusion FISH Probe
The CRK-GTF2I Fusion FISH Probe is used to confirm a fusion of the CRK and GTF2I genes. The fusion of the CRK and GTF2I genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CRK-GTF2I-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-RERE | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-REOR | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-REGO | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-REGR | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-REAQ | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-ORRE | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-OROR | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-ORGO | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-ORAQ | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-GORE | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-GOOR | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-GOGO | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-GOGR | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-GOAQ | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-GRRE | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-GROR | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-GRGO | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-GRGR | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-GRAQ | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-AQRE | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-AQOR | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-AQGO | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-AQGR | 20 (40 μL) | 200 μL |
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| CRK-GTF2I-20-AQAQ | 20 (40 μL) | 200 μL |
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CRK Gene Summary
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Gene Name: CRK Proto-oncogene, Adaptor Protein
Chromosome: CHR17: 1325457 -1359544
Locus: 17p13.3
GTF2I Gene Summary
This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013]
Gene Name: General Transcription Factor IIi
Chromosome: CHR7: 74072029 -74175022
Locus: 7q11.23
Gene Diseases
The CRK GTF2I Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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