CRIM1-HAAO Fusion FISH Probe
The CRIM1-HAAO Fusion FISH Probe is used to confirm a fusion of the CRIM1 and HAAO genes. The fusion of the CRIM1 and HAAO genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CRIM1-HAAO-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-RERE | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-REOR | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-REGO | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-REGR | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-REAQ | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-ORRE | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-OROR | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-ORGO | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-ORAQ | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-GORE | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-GOOR | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-GOGO | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-GOGR | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-GOAQ | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-GRRE | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-GROR | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-GRGO | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-GRGR | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-GRAQ | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-AQRE | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-AQOR | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-AQGO | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-AQGR | 20 (40 μL) | 200 μL |
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| CRIM1-HAAO-20-AQAQ | 20 (40 μL) | 200 μL |
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HAAO Gene Summary
3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
Gene Name: 3-hydroxyanthranilate 3,4-dioxygenase
Chromosome: CHR2: 42994228 -43019751
Locus: 2p21
CRIM1 Gene Summary
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]
Gene Name: Cysteine Rich Transmembrane BMP Regulator 1
Chromosome: CHR2: 36583369 -36778278
Locus: 2p22.2
Gene Diseases
The CRIM1 HAAO Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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