CRHR1-SPOP Fusion FISH Probe
The CRHR1-SPOP Fusion FISH Probe is used to confirm a fusion of the CRHR1 and SPOP genes. The fusion of the CRHR1 and SPOP genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CRHR1-SPOP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-RERE | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-REOR | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-REGO | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-REGR | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-REAQ | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-ORRE | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-OROR | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-ORGO | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-ORAQ | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-GORE | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-GOOR | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-GOGO | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-GOGR | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-GOAQ | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-GRRE | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-GROR | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-GRGO | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-GRGR | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-GRAQ | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-AQRE | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-AQOR | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-AQGO | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-AQGR | 20 (40 μL) | 200 μL |
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| CRHR1-SPOP-20-AQAQ | 20 (40 μL) | 200 μL |
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CRHR1 Gene Summary
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016]
Gene Name: Corticotropin Releasing Hormone Receptor 1
Chromosome: CHR17_ctg5_hap1: 954314 -1170453
Locus: 17q21.31
SPOP Gene Summary
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Name: Speckle Type BTB/POZ Protein
Chromosome: CHR17: 47676245 -47755525
Locus: 17q21.33
Gene Diseases
The CRHR1 SPOP Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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