CREBBP-WRAP53 Fusion FISH Probe
The CREBBP-WRAP53 Fusion FISH Probe is used to confirm a fusion of the CREBBP and WRAP53 genes. The fusion of the CREBBP and WRAP53 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CREBBP-WRAP53-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-RERE | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-REOR | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-REGO | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-REGR | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-REAQ | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-ORRE | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-OROR | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-ORGO | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-ORAQ | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-GORE | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-GOOR | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-GOGO | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-GOGR | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-GOAQ | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-GRRE | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-GROR | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-GRGO | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-GRGR | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-GRAQ | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-AQRE | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-AQOR | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-AQGO | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-AQGR | 20 (40 μL) | 200 μL |
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| CREBBP-WRAP53-20-AQAQ | 20 (40 μL) | 200 μL |
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CREBBP Gene Summary
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Gene Name: CREB Binding Protein
Chromosome: CHR16: 3775055 -3930121
Locus: 16p13.3
WRAP53 Gene Summary
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Name: WD Repeat Containing Antisense To TP53
Chromosome: CHR17: 7589388 -7606820
Locus: 17p13.1
Gene Diseases
The CREBBP WRAP53 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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