CREBBP-SRRM2 Fusion FISH Probe
The CREBBP-SRRM2 Fusion FISH Probe is used to confirm a fusion of the CREBBP and SRRM2 genes. The fusion of the CREBBP and SRRM2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CREBBP-SRRM2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-RERE | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-REOR | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-REGO | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-REGR | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-REAQ | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-ORRE | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-OROR | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-ORGO | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-GORE | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-GOOR | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-GOGO | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-GOGR | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-GRRE | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-GROR | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-GRGO | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-GRGR | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-AQRE | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-AQOR | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-AQGO | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-AQGR | 20 (40 μL) | 200 μL |
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| CREBBP-SRRM2-20-AQAQ | 20 (40 μL) | 200 μL |
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CREBBP Gene Summary
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Gene Name: CREB Binding Protein
Chromosome: CHR16: 3775055 -3930121
Locus: 16p13.3
SRRM2 Gene Summary
The Serine/arginine Repetitive Matrix 2 (SRRM2) gene is located on chr16 :2802329-2821413 at 16p13.3.
Gene Name: Serine/arginine Repetitive Matrix 2
Chromosome: CHR16: 2802329 -2821413
Locus: 16p13.3
Gene Diseases
The CREBBP SRRM2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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