CREBBP-RANBP3 Fusion FISH Probe
The CREBBP-RANBP3 Fusion FISH Probe is used to confirm a fusion of the CREBBP and RANBP3 genes. The fusion of the CREBBP and RANBP3 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CREBBP-RANBP3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-RERE | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-REOR | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-REGO | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-REGR | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-REAQ | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-ORRE | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-OROR | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-ORGO | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-GORE | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-GOOR | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-GOGO | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-GOGR | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-GRRE | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-GROR | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-GRGO | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-GRGR | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-AQRE | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-AQOR | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-AQGO | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-AQGR | 20 (40 μL) | 200 μL |
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| CREBBP-RANBP3-20-AQAQ | 20 (40 μL) | 200 μL |
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CREBBP Gene Summary
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Gene Name: CREB Binding Protein
Chromosome: CHR16: 3775055 -3930121
Locus: 16p13.3
RANBP3 Gene Summary
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: RAN Binding Protein 3
Chromosome: CHR19: 5916151 -5978320
Locus: 19p13.3
Gene Diseases
The CREBBP RANBP3 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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