CREBBP-HCN1 Fusion FISH Probe
The CREBBP-HCN1 Fusion FISH Probe is used to confirm a fusion of the CREBBP and HCN1 genes. The fusion of the CREBBP and HCN1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CREBBP-HCN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-RERE | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-REOR | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-REGO | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-REGR | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-REAQ | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-ORRE | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-OROR | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-ORGO | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-GORE | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-GOOR | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-GOGO | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-GOGR | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-GRRE | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-GROR | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-GRGO | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-GRGR | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-AQRE | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-AQOR | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-AQGO | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-AQGR | 20 (40 μL) | 200 μL |
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| CREBBP-HCN1-20-AQAQ | 20 (40 μL) | 200 μL |
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CREBBP Gene Summary
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Gene Name: CREB Binding Protein
Chromosome: CHR16: 3775055 -3930121
Locus: 16p13.3
HCN1 Gene Summary
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]
Gene Name: Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1
Chromosome: CHR5: 45259351 -45696220
Locus: 5p12
Gene Diseases
The CREBBP HCN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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