CREBBP-ATG10 Fusion FISH Probe
The CREBBP-ATG10 Fusion FISH Probe is used to confirm a fusion of the CREBBP and ATG10 genes. The fusion of the CREBBP and ATG10 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CREBBP-ATG10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-RERE | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-REOR | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-REGO | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-REGR | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-REAQ | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-ORRE | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-OROR | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-ORGO | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-ORAQ | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-GORE | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-GOOR | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-GOGO | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-GOGR | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-GOAQ | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-GRRE | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-GROR | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-GRGO | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-GRGR | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-GRAQ | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-AQRE | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-AQOR | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-AQGO | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-AQGR | 20 (40 μL) | 200 μL |
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| CREBBP-ATG10-20-AQAQ | 20 (40 μL) | 200 μL |
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CREBBP Gene Summary
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Gene Name: CREB Binding Protein
Chromosome: CHR16: 3775055 -3930121
Locus: 16p13.3
ATG10 Gene Summary
Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]
Gene Name: Autophagy Related 10
Chromosome: CHR5: 81267843 -81551216
Locus: 5q14.1-q14.2
Gene Diseases
The CREBBP ATG10 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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