CRADD-MRPL42 Fusion FISH Probe
The CRADD-MRPL42 Fusion FISH Probe is used to confirm a fusion of the CRADD and MRPL42 genes. The fusion of the CRADD and MRPL42 genes has been associated with Stomach Adenocarcinoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CRADD-MRPL42-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-RERE | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-REOR | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-REGO | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-REGR | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-OROR | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-GORE | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-GROR | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| CRADD-MRPL42-20-AQAQ | 20 (40 μL) | 200 μL |
|
CRADD Gene Summary
This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: CASP2 And RIPK1 Domain Containing Adaptor With Death Domain
Chromosome: CHR12: 94071150 -94244531
Locus: 12q22
MRPL42 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by RefSeq, May 2011]
Gene Name: Mitochondrial Ribosomal Protein L42
Chromosome: CHR12: 93861265 -93897548
Locus: 12q22
Gene Diseases
The CRADD MRPL42 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Stomach Adenocarcinoma |
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|