CPT1A-P4HA3 Fusion FISH Probe
The CPT1A-P4HA3 Fusion FISH Probe is used to confirm a fusion of the CPT1A and P4HA3 genes. The fusion of the CPT1A and P4HA3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CPT1A-P4HA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-RERE | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-REOR | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-REGO | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-REGR | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-REAQ | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-ORRE | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-OROR | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-ORGO | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-GORE | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-GOOR | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-GOGO | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-GOGR | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-GRRE | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-GROR | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-GRGO | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-GRGR | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-AQRE | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-AQOR | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-AQGO | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-AQGR | 20 (40 μL) | 200 μL |
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| CPT1A-P4HA3-20-AQAQ | 20 (40 μL) | 200 μL |
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CPT1A Gene Summary
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Carnitine Palmitoyltransferase 1A
Chromosome: CHR11: 68522087 -68609399
Locus: 11q13.3
P4HA3 Gene Summary
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Name: Prolyl 4-hydroxylase Subunit Alpha 3
Chromosome: CHR11: 73977701 -74022699
Locus: 11q13.4
Gene Diseases
The CPT1A P4HA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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