CPT1A-LPXN Fusion FISH Probe
The CPT1A-LPXN Fusion FISH Probe is used to confirm a fusion of the CPT1A and LPXN genes. The fusion of the CPT1A and LPXN genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CPT1A-LPXN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-RERE | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-REOR | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-REGO | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-REGR | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-REAQ | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-ORRE | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-OROR | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-ORGO | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-ORAQ | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-GORE | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-GOOR | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-GOGO | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-GOGR | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-GOAQ | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-GRRE | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-GROR | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-GRGO | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-GRGR | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-GRAQ | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-AQRE | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-AQOR | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-AQGO | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-AQGR | 20 (40 μL) | 200 μL |
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| CPT1A-LPXN-20-AQAQ | 20 (40 μL) | 200 μL |
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CPT1A Gene Summary
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Carnitine Palmitoyltransferase 1A
Chromosome: CHR11: 68522087 -68609399
Locus: 11q13.3
LPXN Gene Summary
The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Gene Name: Leupaxin
Chromosome: CHR11: 58294343 -58345639
Locus: 11q12.1
Gene Diseases
The CPT1A LPXN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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