CPT1A-ANPEP Fusion FISH Probe
The CPT1A-ANPEP Fusion FISH Probe is used to confirm a fusion of the CPT1A and ANPEP genes. The fusion of the CPT1A and ANPEP genes has been associated with Kidney Renal Clear Cell Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CPT1A-ANPEP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-RERE | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-REOR | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-REGO | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-REGR | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-REAQ | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-ORRE | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-OROR | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-ORGO | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-ORAQ | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-GORE | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-GOOR | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-GOGO | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-GOGR | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-GOAQ | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-GRRE | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-GROR | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-GRGO | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-GRGR | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-GRAQ | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-AQRE | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-AQOR | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-AQGO | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-AQGR | 20 (40 μL) | 200 μL |
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| CPT1A-ANPEP-20-AQAQ | 20 (40 μL) | 200 μL |
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ANPEP Gene Summary
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
Gene Name: Alanyl Aminopeptidase, Membrane
Chromosome: CHR15: 90328125 -90358072
Locus: 15q26.1
CPT1A Gene Summary
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Carnitine Palmitoyltransferase 1A
Chromosome: CHR11: 68522087 -68609399
Locus: 11q13.3
Gene Diseases
The CPT1A ANPEP Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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