CPSF6-PTPRB Fusion FISH Probe
The CPSF6-PTPRB Fusion FISH Probe is used to confirm a fusion of the CPSF6 and PTPRB genes. The fusion of the CPSF6 and PTPRB genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CPSF6-PTPRB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-RERE | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-REOR | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-REGO | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-REGR | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-REAQ | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-ORRE | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-OROR | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-ORGO | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-ORAQ | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-GORE | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-GOOR | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-GOGO | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-GOGR | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-GOAQ | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-GRRE | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-GROR | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-GRGO | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-GRGR | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-GRAQ | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-AQRE | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-AQOR | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-AQGO | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-AQGR | 20 (40 μL) | 200 μL |
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| CPSF6-PTPRB-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRB Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type B
Chromosome: CHR12: 70910631 -71031220
Locus: 12q15
CPSF6 Gene Summary
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
Gene Name: Cleavage And Polyadenylation Specific Factor 6
Chromosome: CHR12: 69633316 -69668138
Locus: 12q15
Gene Diseases
The CPSF6 PTPRB Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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