CPSF6-LAMA2 Fusion FISH Probe
The CPSF6-LAMA2 Fusion FISH Probe is used to confirm a fusion of the CPSF6 and LAMA2 genes. The fusion of the CPSF6 and LAMA2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CPSF6-LAMA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-RERE | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-REOR | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-REGO | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-REGR | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-REAQ | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-ORRE | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-OROR | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-ORGO | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-GORE | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-GOOR | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-GOGO | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-GOGR | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-GRRE | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-GROR | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-GRGO | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-GRGR | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-AQRE | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-AQOR | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-AQGO | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-AQGR | 20 (40 μL) | 200 μL |
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| CPSF6-LAMA2-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMA2 Gene Summary
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Laminin Subunit Alpha 2
Chromosome: CHR6: 129204285 -129837710
Locus: 6q22.33
CPSF6 Gene Summary
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
Gene Name: Cleavage And Polyadenylation Specific Factor 6
Chromosome: CHR12: 69633316 -69668138
Locus: 12q15
Gene Diseases
The CPSF6 LAMA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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