CPSF6-GRM8 Fusion FISH Probe
The CPSF6-GRM8 Fusion FISH Probe is used to confirm a fusion of the CPSF6 and GRM8 genes. The fusion of the CPSF6 and GRM8 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CPSF6-GRM8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-RERE | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-REOR | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-REGO | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-REGR | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-REAQ | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-ORRE | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-OROR | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-ORGO | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-ORAQ | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-GORE | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-GOOR | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-GOGO | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-GOGR | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-GOAQ | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-GRRE | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-GROR | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-GRGO | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-GRGR | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-GRAQ | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-AQRE | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-AQOR | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-AQGO | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-AQGR | 20 (40 μL) | 200 μL |
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| CPSF6-GRM8-20-AQAQ | 20 (40 μL) | 200 μL |
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GRM8 Gene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Glutamate Metabotropic Receptor 8
Chromosome: CHR7: 126078651 -126892428
Locus: 7q31.33
CPSF6 Gene Summary
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
Gene Name: Cleavage And Polyadenylation Specific Factor 6
Chromosome: CHR12: 69633316 -69668138
Locus: 12q15
Gene Diseases
The CPSF6 GRM8 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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