CPS1-PLCD4 Fusion FISH Probe
The CPS1-PLCD4 Fusion FISH Probe is used to confirm a fusion of the CPS1 and PLCD4 genes. The fusion of the CPS1 and PLCD4 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CPS1-PLCD4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-RERE | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-REOR | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-REGO | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-REGR | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-REAQ | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-ORRE | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-OROR | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-ORGO | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-GORE | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-GOOR | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-GOGO | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-GOGR | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-GRRE | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-GROR | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-GRGO | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-GRGR | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-AQRE | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-AQOR | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-AQGO | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-AQGR | 20 (40 μL) | 200 μL |
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| CPS1-PLCD4-20-AQAQ | 20 (40 μL) | 200 μL |
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CPS1 Gene Summary
The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation.[provided by RefSeq, May 2010]
Gene Name: Carbamoyl-phosphate Synthase 1
Chromosome: CHR2: 211342405 -211543831
Locus: 2q34
PLCD4 Gene Summary
This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]
Gene Name: Phospholipase C Delta 4
Chromosome: CHR2: 219472487 -219501909
Locus: 2q35
Gene Diseases
The CPS1 PLCD4 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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