CPNE8-CILP Fusion FISH Probe
The CPNE8-CILP Fusion FISH Probe is used to confirm a fusion of the CPNE8 and CILP genes. The fusion of the CPNE8 and CILP genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CPNE8-CILP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-RERE | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-REOR | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-REGO | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-REGR | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-REAQ | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-ORRE | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-OROR | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-ORGO | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-ORAQ | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-GORE | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-GOOR | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-GOGO | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-GOGR | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-GOAQ | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-GRRE | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-GROR | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-GRGO | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-GRGR | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-GRAQ | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-AQRE | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-AQOR | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-AQGO | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-AQGR | 20 (40 μL) | 200 μL |
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| CPNE8-CILP-20-AQAQ | 20 (40 μL) | 200 μL |
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CILP Gene Summary
Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010]
Gene Name: Cartilage Intermediate Layer Protein
Chromosome: CHR15: 65488336 -65503840
Locus: 15q22.31
CPNE8 Gene Summary
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]
Gene Name: Copine 8
Chromosome: CHR12: 39046001 -39299420
Locus: 12q12
Gene Diseases
The CPNE8 CILP Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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