CPM-BEST3 Fusion FISH Probe
The CPM-BEST3 Fusion FISH Probe is used to confirm a fusion of the CPM and BEST3 genes. The fusion of the CPM and BEST3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CPM-BEST3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-RERE | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-REOR | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-REGO | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-REGR | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-REAQ | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-ORRE | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-OROR | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-ORGO | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-GORE | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-GOOR | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-GOGO | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-GOGR | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-GRRE | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-GROR | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-GRGO | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-GRGR | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-AQRE | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-AQOR | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-AQGO | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-AQGR | 20 (40 μL) | 200 μL |
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| CPM-BEST3-20-AQAQ | 20 (40 μL) | 200 μL |
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CPM Gene Summary
The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Carboxypeptidase M
Chromosome: CHR12: 69244955 -69357020
Locus: 12q15
BEST3 Gene Summary
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]
Gene Name: Bestrophin 3
Chromosome: CHR12: 70047388 -70093196
Locus: 12q15
Gene Diseases
The CPM BEST3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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