CPLX1-GAK Fusion FISH Probe
The CPLX1-GAK Fusion FISH Probe is used to confirm a fusion of the CPLX1 and GAK genes. The fusion of the CPLX1 and GAK genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CPLX1-GAK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-RERE | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-REOR | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-REGO | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-REGR | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-REAQ | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-ORRE | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-OROR | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-ORGO | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-ORAQ | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-GORE | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-GOOR | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-GOGO | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-GOGR | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-GOAQ | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-GRRE | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-GROR | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-GRGO | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-GRGR | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-GRAQ | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-AQRE | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-AQOR | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-AQGO | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-AQGR | 20 (40 μL) | 200 μL |
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| CPLX1-GAK-20-AQAQ | 20 (40 μL) | 200 μL |
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GAK Gene Summary
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: Cyclin G Associated Kinase
Chromosome: CHR4: 843064 -926174
Locus: 4p16.3
CPLX1 Gene Summary
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]
Gene Name: Complexin 1
Chromosome: CHR4: 778744 -819945
Locus: 4p16.3
Gene Diseases
The CPLX1 GAK Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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