CPE-ARHGEF4 Fusion FISH Probe
The CPE-ARHGEF4 Fusion FISH Probe is used to confirm a fusion of the CPE and ARHGEF4 genes. The fusion of the CPE and ARHGEF4 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CPE-ARHGEF4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-RERE | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-REOR | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-REGO | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-REGR | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-REAQ | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-ORRE | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-OROR | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-ORGO | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-ORAQ | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-GORE | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-GOOR | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-GOGO | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-GOGR | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-GOAQ | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-GRRE | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-GROR | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-GRGO | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-GRGR | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-GRAQ | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-AQRE | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-AQOR | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-AQGO | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-AQGR | 20 (40 μL) | 200 μL |
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| CPE-ARHGEF4-20-AQAQ | 20 (40 μL) | 200 μL |
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CPE Gene Summary
This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
Gene Name: Carboxypeptidase E
Chromosome: CHR4: 166300096 -166419482
Locus: 4q32.3
ARHGEF4 Gene Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]
Gene Name: Rho Guanine Nucleotide Exchange Factor 4
Chromosome: CHR2: 131674223 -131804836
Locus: 2q21.1
Gene Diseases
The CPE ARHGEF4 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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